Enrofloxacin (ENR) is a fluoroquinolone antibiotic sold by the Bayer Corporation under the trade name Baytril. It is a bactericidal agent. The bactericidal activity of enrofloxacin is concentration-dependent, with susceptible bacteria cell death occurring within 20–30 minutes of exposure. Enrofloxacin has demonstrated a significant post-antibiotic effect for both Gram-negative and Gram-positive bacteria. This being it is a broad spectrum antibiotic
LD (Lethal Dose Information)
It is unlikely that an acute overdose of either compound would result in symptoms more serious than either anorexia or vomiting, but the adverse effects noted above could occur. Dogs receiving 10 times the labeled dosage rate of enrofloxacin for at least 14 days developed only vomiting and anorexia.
Death did occur in some dogs when fed 25 times the labeled rate for 11 days, however. Oral LD50: greater than 5000 mg/kg Dermal LD50: greater than 2000 mg/kg Inhalation LD50: greater than 3547 mg/m3 (4-hour exposure) Eye effects: irritant; reversible in less than 7 days.
Tablets: 5.7 mg, 22.7 mg, 68 mg, & 136 mg Can be made into suspension.
Also comes as 22.7 mg/mL in 20 mL vials, or 5% solution in 20 mL vials for injection.
Particularly useful for ailments such as: respiratory infections, urinary tract infections, soft tissue infection and soft tissue injury. Dosage Recommendations:
If choosing to use Baytril 10%, keep in mind it has a concentration of 100 mg per 1 mL. Also, because the injectable can be so caustic to tissue it must be diluted for all routes. 5 mg/kg to 20 mg/kg (Allow your vet to verify)
Caution with injection dose as these routes can cause tissue necrosis and pain at the site. Dilute with sterile saline before injection. Further Notes: Because enrofloxacin may cause skin ulceration (tissue necrosis), and pain, at the injection site; it is recommended to dilute the injectable solution with sterile saline or LRS.
Be sure to keep animals well hydrated to prevent crystalluria (formation of crystals in urine). Reconstituted suspension from powder should be kept refrigerated and has a 14 day expiration time. Injectable Baytril should be stored away from direct sunlight.
Do not refrigerate the injectable form, freeze or store at or above 40°C (104°F). Precipitation may occur at cold temperature. To redissolve, warm and then shake the vial. Enrofloxacin is generally used simultaneously with doxycycline however Pouched Rats may be intolerant to doxycyline.
Please note that it is imperative to discuss the changing or adding of any medications during your rat’s treatment with your veterinarian to prevent future resistance of microbes to the drugs prescribed.
Courses of antibiotics should always be completed as per your veterinarians recommendations.